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Sodium aurothiomalate

CAS No. 12244-57-4

Sodium aurothiomalate( gold sodium thiomalate | Aurothiomalate sodium | Miochrysin | Myochrysine | Myocrisin | Myocrisine )

Catalog No. M23393 CAS No. 12244-57-4

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 65 In Stock
25MG 132 In Stock
50MG 205 In Stock
100MG 335 In Stock
200MG 494 In Stock
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Biological Information

  • Product Name
    Sodium aurothiomalate
  • Note
    Research use only, not for human use.
  • Brief Description
    Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects.
  • Description
    Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium exhibits potent anti-tumor activity.
  • In Vitro
    Western Blot Analysis Cell Line:Bovine arterial endothelial cells (BAEC)Concentration:25 uM Incubation Time:6 hours Result:Suppressed TNFa-induced NF-kB-dependent gene expression in a dose-dependent manner.
  • In Vivo
    Animal Model:4-6-week-old female nude mice with A427 or H460 cells Dosage:2, 6, 20 or 60 mg/kg Administration:Intramuscular injections; daily; 40 days Result:Exhibited statistically significant inhibition of tumor growth at all concentrations tested in A427 cell tumors because A427 cells are highly responsive.
  • Synonyms
    gold sodium thiomalate | Aurothiomalate sodium | Miochrysin | Myochrysine | Myocrisin | Myocrisine
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC-ι|TrxR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    12244-57-4
  • Formula Weight
    390.07
  • Molecular Formula
    C4H3AuNa2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    OC(CC(S)C(O)=O)=O.[x].[Na].[Au]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nummenmaa E, H?m?l?inen M, Moilanen LJ, Moilanen T, Vuolteenaho K, Moilanen E. TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis. RMD Open. 2017 Sep 4;3(2):e000556.
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